Fig. 1From: E3 ubiquitin ligase RNF180 prevents excessive PCDH10 methylation to suppress the proliferation and metastasis of gastric cancer cells by promoting ubiquitination of DNMT1PCDH10 is downregulated in human gastric cancer (GC) cells, which is associated with poor clinical outcome. A PCDH10 expression in human GC tissue samples from TCGA and Genotype-Tissue Expression (GTEx) database. B PCDH10 mRNA levels in 40 pairs of GC tissues and matched normal tissues. C, D PCDH10 protein levels in 20 pairs of GC and matched normal tissues. (E, F) PCDH10 mRNA and protein levels in GC cell lines and GES-1. G, H Representative images of immunohistochemical staining for RNF180 in GC tissues and adjacent nontumor tissues. I, J Low expression of PCDH10 in human GC tissues is associated with poor clinical outcome. *p < 0.05, ***p < 0.001, ****p < 0.0001. T Tumor; N NormalBack to article page