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Fig. 1 | Clinical Epigenetics

Fig. 1

From: E3 ubiquitin ligase RNF180 prevents excessive PCDH10 methylation to suppress the proliferation and metastasis of gastric cancer cells by promoting ubiquitination of DNMT1

Fig. 1

PCDH10 is downregulated in human gastric cancer (GC) cells, which is associated with poor clinical outcome. A PCDH10 expression in human GC tissue samples from TCGA and Genotype-Tissue Expression (GTEx) database. B PCDH10 mRNA levels in 40 pairs of GC tissues and matched normal tissues. C, D PCDH10 protein levels in 20 pairs of GC and matched normal tissues. (E, F) PCDH10 mRNA and protein levels in GC cell lines and GES-1. G, H Representative images of immunohistochemical staining for RNF180 in GC tissues and adjacent nontumor tissues. I, J Low expression of PCDH10 in human GC tissues is associated with poor clinical outcome. *p < 0.05, ***p < 0.001, ****p < 0.0001. T Tumor; N Normal

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