The impact of epigenetic landscape on ovarian cells in infertile older women undergoing IVF procedures

Clinical Epigenetics

Table 1 List of epigenetic modifiers involved in fertility process.

Epigenetic player	Expression level	Target (gene or relative pathway)	Cell/Tissue	References
SIRT1/2/3	↑	H3K9 acetylation	Post-ovulatory aged oocytes	[31]
SIRT1	↑	Telomere homeostasis	Cumulus cells	[20]
SIRT1	↑	Akt; mTOR	Primordial follicles	[34]
SIRT3 and SIRT5	↑	Urea cycle	Granulosa and CCs	[38]
SIRT1	↑	EDN2	Granulosa-lutein cells (hGLCs)	[35]
MeCP2	↑	CYP19A1	CCs	[44]
miR-29a-3p	↑	DNMT3A	Old oocytes	[59]
miR-203a-3p	↑	DNMT3B	Old oocytes	[59]
miR-29b	↑	DNMT3A/B and TET1	Porcine early embryo development	[67]
mito-miRNAs (miR-19a-3p, miR-30a-5p, miR-125b-5p, miR-132-3p and miR-660-5p)	↓	SIRT1, TNF-a, AKT	Follicular fluid	[73]
miRNAs 483-3p, 363-3p, and 4284	↓	Transforming growth factor (TGF)-β signalling pathway	Granulosa cells	[54]
lncRNA Neat1	↑	Luteal genes	Corpus luteum	[79]
lncRNA H19	↓	AMH (anti-müllerian hormone); miR-93-5p and miR-193a-3p	Serum and cumulus cells	[80, 81]
Long intergenic non-protein coding RNA 1001 (LINC01001)	↓	PTEN and SIRT1	CCs	[81]

ISSN: 1868-7083