Table 2 Summary of immune cell parameters based on DNA methylation deconvolution estimates for the entire cohort
Mean | (95% CI) | Median | Percentile range (2.5–97.5) | |
|---|---|---|---|---|
WBC* | 6276.028 | (6173.04, 6379.015) | 6000 | (3386.5, 10,680.25) |
Leukocyte subtypes | ||||
Myeloid** | ||||
Cells/µl | 4394.189 | (4304.664, 4483.714) | 4198.418 | (1893.226, 8212.533) |
% | 69.161 | (68.621, 69.701) | 69.949 | (46.791, 86.387) |
Granulocytes** | ||||
Cells/µl | 3848.037 | (3763.108, 3932.967) | 3668.982 | (1503.92, 7470.417) |
% | 60.231 | (59.648, 60.815) | 60.94 | (36.342, 78.904) |
Neutrophils | ||||
Cells/µl | 3642.355 | (3558.256, 3726.454) | 3469.95 | (1334.334, 7201.745) |
% | 56.833 | (56.207, 57.459) | 57.457 | (31.576, 76.845) |
Basophils | ||||
Cells/µl | 65.7 | (61.971, 69.43) | 41.723 | (18.371, 242.819) |
% | 1.08 | (1.018, 1.141) | 0.6 | (0.478, 3.474) |
Eosinophils | ||||
Cells/µl | 139.982 | (133.382, 146.582) | 112.492 | (19.425, 444) |
% | 2.319 | (2.219, 2.418) | 2 | (0.422, 6.539) |
Monocytes | ||||
Cells/µl | 546.152 | (536.271, 556.033) | 524.352 | (261.548, 961.111) |
% | 8.929 | (8.801, 9.058) | 8.66 | (4.931, 14.337) |
Lymphocytes** | ||||
Cells/µl | 1920.642 | (1881.476, 1959.808) | 1822.981 | (842.129, 3620.853) |
% | 31.465 | (30.92, 32.01) | 30.507 | (14.382, 54.122) |
T cells** | ||||
Cells/µl | 1358.107 | (1327.532, 1388.681) | 1280.328 | (525.1, 2645.941) |
% | 22.247 | (21.809, 22.685) | 21.155 | (9.341, 40.643) |
CD4+ total** | ||||
Cells/µl | 859.971 | (838.43, 881.512) | 794.503 | (296.086, 1799.017) |
% | 14.139 | (13.811, 14.467) | 13.283 | (5.096, 28.434) |
CD4+ memory | ||||
Cells/µl | 609.586 | (593.698, 625.473) | 564.328 | (170.535, 1328.026) |
% | 10.058 | (9.81, 10.306) | 9.378 | (2.796, 21.22) |
CD4+ naïve | ||||
Cells/µl | 200.559 | (190.288, 210.829) | 132.151 | (34.738, 685.529) |
% | 3.283 | (3.118, 3.447) | 2.28 | (0.878, 11.362) |
T regulatory | ||||
Cells/µl | 49.826 | (48.874, 50.779) | 46.956 | (26.777, 87.899) |
% | 0.798 | (0.785, 0.81) | 0.78 | (0.78, 0.78) |
CD8+ total** | ||||
Cells/µl | 498.136 | (476.832, 519.44) | 397.338 | (84.81, 1473.431) |
% | 8.108 | (7.793, 8.423) | 6.715 | (1.559, 22.443) |
CD8+ memory | ||||
Cells/µl | 418.013 | (396.375, 439.651) | 306.012 | (37.325, 1385.639) |
% | 6.803 | (6.478, 7.128) | 5.278 | (0.801, 21.569) |
CD8+ naïve | ||||
Cells/µl | 80.123 | (76.878, 83.368) | 58.101 | (28.146, 246.615) |
% | 1.305 | (1.253, 1.357) | 0.758 | (0.758, 4.127) |
B cells** | ||||
Cells/µl | 227.216 | (218.517, 235.914) | 189.396 | (50.299, 640.404) |
% | 3.755 | (3.617, 3.893) | 3.183 | (0.811, 9.76) |
B memory | ||||
Cells/µl | 86.814 | (81.799, 91.829) | 67.363 | (16.061, 255.53) |
% | 1.412 | (1.335, 1.489) | 1.172 | (0.328, 4.097) |
B naïve | ||||
Cells/µl | 140.402 | (133.852, 146.952) | 106.589 | (23.055, 503.33) |
% | 2.343 | (2.234, 2.452) | 1.834 | (0.483, 7.108) |
Natural killer | ||||
Cells/µl | 335.32 | (326.172, 344.467) | 308.259 | (94.861, 761.925) |
% | 5.463 | (5.331, 5.596) | 5.144 | (1.587, 11.042) |
Cell ratios | ||||
Neutrophil/lymphocyte | 2.162 | (2.087, 2.236) | 1.879 | (0.597, 5.281) |
Lymphocyte/monocyte | 3.699 | (3.625, 3.774) | 3.502 | (1.635, 6.829) |
Eosinophil/lymphocyte | 0.077 | (0.073, 0.081) | 0.063 | (0.012, 0.253) |
Basophil/lymphocyte | 0.038 | (0.035, 0.04) | 0.024 | (0.01, 0.134) |
Eosinophil/neutrophil | 0.046 | (0.044, 0.048) | 0.035 | (0.006, 0.155) |
(Eosinophil + Basophil)/neutrophil | 0.067 | (0.064, 0.071) | 0.053 | (0.012, 0.209) |
Neutrophil/monocyte | 7.126 | (6.88, 7.372) | 6.482 | (2.855, 14.15) |
CD4/CD8 | 3.012 | (2.857, 3.166) | 2.063 | (0.35, 11.097) |
CD4nv/CD8nv | 3.014 | (2.854, 3.174) | 1.832 | (0.419, 11.073) |
CD4mem/CD8mem | 3.806 | (3.563, 4.049) | 1.903 | (0.275, 15.93) |
CD4nv/CD4 | 0.218 | (0.211, 0.226) | 0.189 | (0.047, 0.518) |
CD4nv/CD4mem | 0.365 | (0.347, 0.383) | 0.256 | (0.052, 1.252) |
CD8nv/CD8 | 0.266 | (0.254, 0.279) | 0.173 | (0.034, 0.769) |
CD8nv/CD8mem | 0.61 | (0.561, 0.659) | 0.209 | (0.035, 3.331) |
Treg/CD4 | 0.069 | (0.066, 0.071) | 0.059 | (0.027, 0.165) |
Bnv/B | 0.591 | (0.579, 0.602) | 0.607 | (0.177, 0.919) |
Bnv/Bmem | 2.628 | (2.44, 2.816) | 1.544 | (0.215, 11.359) |
CD8/B | 3.107 | (2.918, 3.296) | 1.999 | (0.357, 12.643) |
(CD8+ NK)/Mono | 1.604 | (1.555, 1.653) | 1.427 | (0.498, 3.788) |
CD8mem/Treg | 8.684 | (8.269, 9.1) | 6.752 | (1.027, 27.648) |