Fig. 4

Immune cell profiles in paired, longitudinal samples. A, B Box plots showing the change in (A) proportion estimates and (B) absolute counts for paired samples. Change was calculated as the difference from the baseline visit to the LLS visit for a pair of samples (LLS estimate—baseline estimate). Red dashed line is at a change of 0. Starred cell types indicate p-value < 0.05 when conducting a paired t-test. C, D Scatter plots of the rate of change for longitudinal samples by age of the subject. Each point is the difference in proportion per year (C) or difference in absolute counts per year (D) from the baseline visit to the LLS visit for a pair of samples for a given subject. The points are colored in by the number of years between the pair of samples. Pearson correlation coefficients and p-values for associations between rate of change and age at baseline are below each cell type plot