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Fig. 8 | Clinical Epigenetics

Fig. 8

From: Short-chain fatty acid-butyric acid ameliorates granulosa cells inflammation through regulating METTL3-mediated N6-methyladenosine modification of FOSL2 in polycystic ovarian syndrome

Fig. 8

Butyric acid improves ovarian inflammation by inhibiting METTL3/FOSL2/NLRP3. Schematic representation of the effect of butyric acid on ovarian inflammation by inhibiting METTL3/FOSL2/NLRP3 pathway. The butyric acid produced by specific intestinal flora enters the blood circulation and finally reached the ovarian tissue. Under normal conditions, butyric acid could downregulate METTL3, thus reducing the m6A modification of FOSL2, finally reduced the downstream inflammatory reaction. In PCOS patients, due to the reduced of butyric acid, disorders of the intestinal flora lead to ovarian inflammation

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Clinical Epigenetics

ISSN: 1868-7083

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