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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Short-chain fatty acid-butyric acid ameliorates granulosa cells inflammation through regulating METTL3-mediated N6-methyladenosine modification of FOSL2 in polycystic ovarian syndrome

Fig. 6

Butyric acid inhibits inflammation through METTL3/FOSL2/NLRP3 pathway. A, B qRT-PCR analysis of m6A motif1 and motif2 and non-peak region in the 3’-UTR of the FOSL2 transcript. Bars represent means ± SD, n = 3. *P < 0.05 for the differences between the indicated groups. C, D On the basis of overexpression of METTL3, we added LPS pretreatment, and then added low concentration butyric acid and high concentration butyric acid to detect the protein expression levels of METTL3, FOSL2 and NLRP3. Bars represent means ± SD, n = 3. *P < 0.05, **P < 0.01. E, F The mRNA expression level of IL-6 and TNF-α in several groups of KGN cells. Bars represent means ± SD, n = 3. *P < 0.05

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Clinical Epigenetics

ISSN: 1868-7083

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