Table 1 The clinicopathological characteristics of enrolled patients in the overall and training cohort
Overall (n = 40) | CRC with PM (n = 17) | CRC without PM (n = 23) | P value | |
|---|---|---|---|---|
Gender | ||||
Female | 25 (62.5) | 13 (76.5) | 12 (52.2) | 0.187 |
Male | 15 (37.5) | 4 (23.5) | 11 (47.8) | |
Age | ||||
Mean(SD) | 53.73 (10.50) | 51.53 (11.81) | 55.35 (9.35) | 0.33 |
Histological type | ||||
Adenocarcinoma | 35 (87.5) | 16 (94.1) | 19 (82.6) | 0.624 |
Mucinous adenocarcinoma | 3 (7.5) | 1 (5.9) | 2 (8.7) | |
Signet ring cell carcinoma | 2 (5.0) | 0 (0.0) | 2 (8.7) | |
Location | ||||
Left | 28 (70.0) | 9 (52.9) | 19 (82.6) | 0.079 |
Right | 12 (30.0) | 8 (47.1) | 4 (17.4) | |
Alcohol tobacco | ||||
No | 36 (90.0) | 14 (82.4) | 22 (95.7) | 0.294 |
Yes | 4 (10.0) | 3 (17.6) | 1 (4.3) | |
TNM_T | ||||
T1 | 2 (5.0) | 0 (0.0) | 2 (8.7) | < 0.001 |
T2 | 1 (2.5) | 0 (0.0) | 1 (4.3) | |
T3 | 23 (57.5) | 5 (29.4) | 18 (78.3) | |
T4 | 10 (25.0) | 9 (52.9) | 1 (4.3) | |
Tis | 1 (2.5) | 0 (0.0) | 1 (4.3) | |
Tx | 3 (7.5) | 3 (17.6) | 0 (0.0) | |
TNM_N | ||||
N0 | 20 (50.0) | 6 (35.3) | 14 (60.9) | 0.154 |
N1 | 10 (25.0) | 5 (29.4) | 5 (21.7) | |
N2 | 7 (17.5) | 3 (17.6) | 4 (17.4) | |
Nx | 3 (7.5) | 3 (17.6) | 0 (0.0) | |
TNM_M | ||||
M0 | 18 (45.0) | 0 (0.0) | 18 (78.3) | < 0.001 |
M1 | 22 (55.0) | 17 (100.0) | 5 (21.7) | |
MSI status | ||||
MSI-H | 1 (2.5) | 0 (0.0) | 1 (4.3) | 1.0 |
MSS | 39 (97.5) | 17 (100.0) | 22 (95.7) | |
TMB in TIS | ||||
Mean(SD) | 5.43 (7.13) | 3.93 (1.75) | 6.55 (9.21) | 0.294 |
PCI scores | ||||
Mean(SD) | 7.40 (11.38) | 17.41 (11.42) | 0.00 (0.00) | < 0.001 |
CA125 (ng/ml) | ||||
Median[IQR] | 19.40 (10.47,34.17) | 35.00 (10.50, 102.20) | 14.50 (10.95, 20.55) | 0.027 |
CA199 (ng/ml) | 0.016 | |||
Median[IQR] | 16.00[7.02, 47.60] | 45.17[10.26, 208.21] | 9.89[4.32, 26.75] | |
CEA (ng/ml) | 0.103 | |||
Median[IQR] | 7.91[3.07, 22.14] | 10.84[4.14, 43.00] | 6.11[2.88, 12.31] | |