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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Peritoneal cell-free DNA as a sensitive biomarker for detection of peritoneal metastasis in colorectal cancer: a prospective diagnostic study

Fig. 4

The mutational frequencies and sites of driver genes in peritoneal cfDNA and tumor tissues of both PM and non-PM. A The detected frequencies of driver gene mutations were consistent in FLD (FLD-PM) and TIS (TIS-PM) of PM, especially TP53, KRAS, APC and BRAF. B In tumor tissue, BRAF mutations were only observed in PM (P < 0.05). C In tumor tissues, 52.9% (9/17) of KRAS mutations, 23.5% (4/17) of BRAF mutations, 17.6% (3/17) of PIK3CA mutation and 23.5%(4/17) of SMAD4 mutation were all observed in PM. Only BRAF mutations were significantly higher in PM than non-PM (P < 0.05)

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Clinical Epigenetics

ISSN: 1868-7083

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