Fig. 8

Potential therapeutic agents for each subtype. A, B Consistency and robustness of two prediction models (CTRP and PRISM), the low expression of STAT3 correlates with sensitivity to 5-fluorouracil (5-FU). C–F The most probable potential therapeutic agents for each subtype. G–J Susceptibility prediction of GC subtypes based on CTRP and PRISM for 4 first-line drugs (5-FU, apatinib, paclitaxel, and cisplatin). ^*P < 0.05, ^**P < 0.01, ^***P < 0.001, ^****P < 0.0001