Fig. 6

Construction and validation of the 6-MRlncRNA prognostic signature in LUAD. A, B The Lasso coefficient values and vertical dashed lines were calculated at the best log (lambda) value. C Lasso coefficient profiles of six prognostic m⁶A-regulated lncRNAs in the signature were displayed. D RT-qPCR was used to examine the relative expression levels of the six m⁶A-regulated lncRNAs in 12 paired LUAD tissues (Tumor) and adjacent non-tumor tissues (Normal). *P < 0.05, not significant (ns) P > 0.05. E, H KM curves of OS for high- and low-risk subgroups in the training set and validation set. F, I ROC curves for the signature and its area under the curve (AUC) value represented 1-, 2-, and 3-year OS prediction in the training set (F) and validation set (I). G, J Risk score distribution plot (upper) showed the distribution of high-risk and low-risk LUAD patients in the training and validation set; Scatter plot (middle) showed the correlation between the survival status and risk score; Heatmap of six risk lncRNAs’ expression (lower) showed the expression distribution in the high-risk and low-risk subgroups