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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Comprehensive analyses of molecular features, prognostic values, and regulatory functionalities of m6A-modified long non-coding RNAs in lung adenocarcinoma

Fig. 2

The expression levels of m6A regulators in LUAD and the correlation between m6A regulators. A Heatmap of the expression levels of m6A regulators (LUAD tumor tissues vs. normal lung tissues) in TCGA and GTEx databases. FC represented the expression fold change of T-median/N-median. WilcoxTest. *P < 0.05, **P < 0.01, ***P < 0.001 and not significant (ns) P > 0.05. B RT-qPCR showed the relative mRNA expression levels of METTL3, METTL14, ALKBH5, FTO, and IGF2BP1/3 in eight paired LUAD tissues (Tumor) and adjacent non-tumor tissues (Normal). Paired t test. **P < 0.01 and not significant (ns) P > 0.05. C, D Western blots showed the protein expression of METTL3, METTL14, FTO, ALKBH5, and IGF2BP1/3 in LUAD tissues (C) and cell lines (D), respectively. E The Pearson correlation analysis of m6A regulators’ expression levels in 872 samples in TCGA and GTEx databases. The number in the circle represented the Pearson coefficient, which determined the size of circle. The cross in the circle represented no correlation (P > 0.001). F The PPI network analysis of m6A regulators. Line thickness indicated the strength of data support

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