Impact of intrauterine exposure to maternal diabetes on preterm birth: fetal DNA methylation alteration is an important mediator

Table 2 CpGs in cord blood associated with intrauterine diabetes exposure

Cpg ID	Coef	SD	P value	Adj P	CH	Coordinate	Target Gene	Genomic location	Relation to CpG Island
cg19032863	0.464	0.085	5.83E−08	0.017	1	90011484	LRRC8B	5'UTR
cg18997837	0.365	0.066	6.06E−08	0.017	1	171882657	DNM3	Body
cg08810410	0.327	0.060	9.22E−08	0.017	1	203300522			S_Shelf
cg21363811	− 0.450	0.088	3.53E−07	0.031	1	179713950	FAM163A	5'UTR	Island
cg24804643	0.433	0.089	1.15E−06	0.045	1	197455252
cg15317464	0.430	0.085	4.65E−07	0.034	2	9105414	MBOAT2	Body
cg25049210	0.438	0.086	3.71E−07	0.031	3	30495126
cg22324029	0.473	0.092	3.31E−07	0.031	6	32908466	HLA-DMB	Body
cg08840298	0.248	0.049	8.32E−07	0.044	9	124044927	GSN	5'UTR Body
cg21747782	0.291	0.057	6.88E−07	0.041	10	126103031	OAT	5'UTR	N_Shelf
cg25953130	0.458	0.094	1.24E−06	0.045	10	63753550	ARID5B	Body
cg09191149	0.460	0.093	8.70E−07	0.044	16	10962161
cg00938688	0.381	0.077	9.34E−07	0.044	16	11862556	ZC3H7A	Body
cg04384031	0.340	0.063	1.03E−07	0.017	17	19631485			S_Shelf
cg04492567	0.326	0.062	2.35E−07	0.031	17	19631464			S_Shelf
cg07408552	0.426	0.087	1.00E−06	0.044	17	40611995	ATP6V0A1	5'UTR	S_Shore
cg09915396	0.345	0.070	1.07E−06	0.044	17	2907895	RAP1GAP2	Body
cg18575710	0.431	0.085	5.30E−07	0.035	22	28569035	TTC28	Body

Adj P P value adjusted by multiple test correction, CH Chromosome, Coef Coefficient
Models were adjusted for maternal age, race and ethnicity, educational attainment, smoking status during pregnancy, prepregnancy overweight or obesity, newborn’s sex, fetal growth status, and cell type composition

ISSN: 1868-7083