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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Neuroglobin plays as tumor suppressor by disrupting the stability of GPR35 in colorectal cancer

Fig. 4

NGB-OE suppresses tumor angiogenesis ability of CRC cells. A Heatmap of differentially expressed proteins in NGB-overexpressing or vector HCT116 cells. B Angiogenesis estimated by endothelial cell tube formation assay; statistical analysis of tube formation and branches is shown on the right used angiogenesis tool of image J, N =  3. CM means conditional medium. C Immunofluorescence: the effect of NGB on CD31 expression status in CRC cells. D The status of angiogenesis pathway detected by WB or WES. E Immunofluorescence: the effect of NGB on VEGFR2 expression in CRC cells. All experiments were performed in triplicate. *p < 0.05, **p < 0.01, ***p < 0.001

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