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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Neuroglobin plays as tumor suppressor by disrupting the stability of GPR35 in colorectal cancer

Fig. 3

NGB inhibits cancer cell proliferation and inhibits tumor growth in vivo and in vitro. A Confirmation of NGB-OE determined by RT-PCR and Western blot (WB). B Cell viability analysis by CCK8 assay. C Analysis of cell proliferation by colony formation assay. D Percentage of in NGB or vector cells distributed in each phase. E Apoptotic ratio in NGB or Vector CRC cells. F Migration of CRC cells with or without NGB-OE; the statistical analysis is shown on the right. G Invasion of CRC cells with or without NGB-OE; the statistical analysis is shown on the right. H Photographs of subcutaneous tumors of nude mice taken after 20 days, N =  6. I The tumor weight was recorded. J The subcutaneous tumor volume of nude mice was measured every two days before the tumor volume exceeded 1 cm.3. *p < 0.05, **p < 0.01, ***p < 0.001

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