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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Sperm DNA methylation is predominantly stable in mice offspring born after transplantation of long-term cultured spermatogonial stem cells

Fig. 2

Differential analysis for CpG sites of the SSCT F1 and F2 compared to control F1. A Volcano plot shows the number of CpGs with changed patterns of CpG methylation between SSCT samples and control samples significantly higher or lower than the 25% difference cut-off and considering a q-value threshold of 0.01. Values on the x- and y-axes are percent methylation differences and negative log10 of the corrected p-values, respectively. B The distribution of differentially methylated CpGs (DMCs) over DNA regions exons, introns, promoters and intergenic regions per generation. F2/M—F2 generated from the maternal line, F2/P—F2 generated from the paternal line

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