Table 4 Association of methylated genes with cardiovascular related diseases

Heart

MIF,CAV2,ACSS2,JARID2,FAM212B,FRMD4A,CHM,TRPM6,PDSS2,NFIA,HTR1D,HS6ST3,DIS3,PARP4,SOX6,DAAM2,DOPEY2,MYO5A,PLA2G4E,HDAC9,MYO1H,ABCB1,GREM1,RPS6KA5,HYOU1

Coronary artery disease in patients with heart failure

I25*

32,618,141 [33]

ST6GALNAC1,HOXA5,EMP1,SULF1,NGEF,SOST,HOXD4,TM4SF1,PLG,TMCO5A,WT1,IKZF1,ALDH1A3,ALX4,THSD4,PAX9,CEP170,S100A10,RNF207,GLRX,SH2D2A,ESR1,ELANE

Coronary artery disease

I25*

25,856,389 [22]

F2RL3, ABTB2

Myocardial Infarction

I21.9

35,012,325 [75], 33,883,000 [79]

ADAMTS2

Cardiac hypertrophy

I42.2

28,373,586 [116]

ZBTB20

Cardiac remodeling

-

33,063,955 [117]

Shared

C7orf50, FBXL13, PRKCZ, KCNQ1, THBS1, PRDM16, DNMT3A, HOXA, HOXC4, TNXB, HOXB3, PTPRN2, SHANK2

Weight loss

R63. 4

25,651,499 [118]

RUNX3, MYLK, GALNT2, TRAPPC9, PRDM16, NR2F2, HOXA3, HOXB3, AXIN2

Congenital heart defects (CHD)

Q24.9

31,186,048 [119], 30,760,879 [120]

PTPRN2, TRAPPC9

Incident coronary heart disease

I25.10

34,627,379 [121]

ACAP2

Myocardial infarction

I21.9

34,139,744 [122]

Vasculature

CD4, CCR5, CD8A, CXCR3

Chronic Chagasic Cardiomyopathy

B57. 2

31,087,713 [123]

CD2, CCR5, CCR2, CD8A

Diabetes mellitus

E11.9

10,400,139 [124]

ARHGEF10

Atherothrombotic stroke

I63.40

20,042,462 [125]

CAMTA1

Cognitive function in adults with cardiovascular disease

-

21,951,953 [126]

COL5A1

Aortic dissection

I71. 010

34,041,919 [127]