Table 3 Top 5 identified CpG sites and genes
Reported in no. of studies | Annotated gene/CpG* | Associated traits** | Total no. of traits | |
|---|---|---|---|---|
CpG | ||||
cg01656216 | 6 | ZNF438 | Heel bone mineral density, rheumatoid arthritis, multiple sclerosis, body height, pulse pressure measurement, | 30 |
cg03636183 | 6 | F2RL3 | Ageing, platelet reactivity measurement | 2 |
cg07553761 | 5 | TRIM59 | Aging, epigenetic status, type II diabetes mellitus, serum alanine aminotransferase measurement, eosinophil count, systolic blood pressure, eosinophil percentage of leukocytes | 18 |
cg09809672 | 5 | EDARADD | Lymphocyte count, autoimmune thyroid disease, PHF-tau measurement, hypothyroidism, response to simvastatin, type II diabetes mellitus, total cholesterol change measurement, response to fenofibrate | 10 |
cg10281002 | 5 | TBX5 | PR interval, atrial fibrillation, electrocardiography, smoking status measurement, systolic blood pressure, smoking status measurement, diastolic blood pressure | 35 |
Gene | ||||
PTPRN2 | 11 | cg01271455, cg05766510, cg22395765, cg23455837, cg19208749, cg16964025, cg14631503, cg08492145, cg22056595, cg25566285, cg04864441, cg02941085, cg20393882, cg25277638, cg14338779, cg13451497, cg09194449, cg09608412, cg17561365 | Gut microbiome measurement, abnormality of refraction, adolescent idiopathic scoliosis, cognitive function measurement, mathematical ability, pathological myopia | 52 |
TEAD1 | 10 | cg25037165, cg19662708, cg19496491, cg18525873, cg06829681, cg04940570 | Self-reported educational attainment, vital capacity, body height, neutrophil count, mathematical ability | 34 |
ZBTB16 | 9 | cg14042099, cg09890653, cg22768358, cg25101936, cg07631435, cg16246188, cg02042026, cg04628008, cg09593860, cg15309093. cg24452821, cg25009965.cg25577489 | lymphocyte count. neutrophil-to-lymphocyte ratio. platelet-to-lymphocyte ratio, eczema, self-reported educational attainment | 30 |
F2RL3 | 9 | cg19006008, cg03636183, cg08067617, cg08200625, cg14021375 | Ageing, platelet reactivity measurement | 2 |
HOXC4 | 8 | cg15233062.cg15700739, cg22198132, cg14108840, cg02491017, cg23697546, cg19186380, cg05408649, cg21493516, cg27138204, cg26201952, cg22370252, cg18473521, cg03146625, cg15648389, cg00243574, cg01683044, cg06714180, cg10005224, cg18843682, cg26035702 | BMI-adjusted waist circumference. systolic blood pressure. smoking behavior, BMI-adjusted waist-hip ratio | 44 |