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Table 4 The cardiac epigenetic age distribution in the risk factors’ different levels

From: Distinguishable DNA methylation defines a cardiac-specific epigenetic clock

Cardiac tissue DeltaAge

AVR (n = 68)

CABG (n = 224)

Ratio AVR/CABG (p value)

Decelerated (%)

Normal (%)

Accelerated (%)

Decelerated (%)

Normal (%)

Accelerated (%)

Decelerated

Normal

Accelerated

BMI < 30 kg/m2

40.7

35.2

24.1

25.3

51.8

22.9

1.6 (0.09)

0.7 (0.10)

1.0 (1.0)

BMI ≥ 30 kg/m2

35.7

42.9

21.4

22.4

37.9

39.7

1.6 (0.90)

1.1 (1.0)

0.54 (0.60)

Smoker

35.0

30.0

35.0

24.4

45.5

30.1

1.43 (0.94)

0.66 (0.58)

1.1 (1.0)

No smoker

41.67

39.5

18.7

25.0

51.0

24.0

1.7 (0.11)

0.78 (0.58)

0.78 (1.0)

  1. Inside each risk factor level, the DeltaAge distribution was evaluated for possible differences between AVR and CABG. Differences between AVR and CABG have been tested using Post Hoc Analysis for Pearson’s Chi-Squared Test with p values adjusted for multiple comparisons by the Benjamini–Hochberg p correction. Even if not significant, the AVR group presented larger percentages of individuals with decelerated DNAmAge