Distinguishable DNA methylation defines a cardiac-specific epigenetic clock

Clinical Epigenetics

Table 3 The different levels of blood epigenetic age distribution in the risk factors

Blood DeltaAge	AVR (n = 74)			CABG (n = 239)			Ratio AVR/CABG (p value)
Blood DeltaAge	Decelerated (%)	Normal (%)	Accelerated (%)	Decelerated (%)	Normal (%)	Accelerated (%)	Decelerated	Normal	Accelerated
BMI < 30 kg/m²	25.9	58.6	15.5	36.0	33.7	30.3	0.72 (0.47)	1.7 (0.002)**	0.5 (0.08)
BMI ≥ 30 kg/m²	43.7	50.0	6.3	25.0	43.7	31.25	1.7 (0.41)	1.14 (1.0)	0.20 (0.1)
Smoker	29.2	62.5	8.3	34.8	31.8	33.3	0.8 (1)	2 (0.01)*	0.25 (0.04)*
No smoker	30.0	54.0	16.0	30.6	41.7	27.8	0.98 (1.0)	1.3 (0.44)	0.6 (0.32)

Inside each risk factor level, the DeltaAge distribution was evaluated for possible differences between AVR and CABG. Notably, most AVR donors with BMI lower than 30 kg/m² had normal DeltaAge. On the other hand, a significantly higher percentage of smoker CABG donors had accelerated DeltaAges. Differences between AVR and CABG have been tested utilizing post hoc analysis for Pearson’s chi-squared test with p values adjusted for multiple comparisons by the Benjamini–Hochberg p correction. Symbols * and ** indicate conditions reaching statistical significance

ISSN: 1868-7083