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Table 1 M&P epigenetic clock formulas

From: Distinguishable DNA methylation defines a cardiac-specific epigenetic clock

M&P epigenetic clocks

Formula

Blood

 + 44.6227153511

 − 0.3019982767*EDARADD(CpG2)

 + 0.2328338368*ELOVL2(CpG2)

 − 0.5749152672*ELOVL2(CpG3)

 − 0.9899312404*ELOVL2(CpG6)

 + 0.6160217020*FHL2(CpG10)

 − 0.9602220285*FHL2(CpG2)

 + 2.4305557761*FHL2(CpG3)

 − 0.1896789356*FHL2(CpG4)

 − 0.0865888452*ITGA2B(CpG2)

 + 1.0970579110*PDE4C(CpG5)

 − 0.0006750886*ASPA(CpG1)2

 + 0.0025856173*ELOVL2(CpG4)2

 + 0.0111994179*ELOVL2(CpG6)2

 − 0.0131271779*FHL2(CpG10)2

 + 0.0095023800*FHL2(CpG2)2

 − 0.0185023682*FHL2 (CpG3)2

 − 0.0102953607*PDE4C (CpG5)2

Heart

 + 70.773560858

 + 0.182565872*EDARADD(CpG1)

 + 0.848763871*ELOVL2(CpG2)

 + 0.100544271*ELOVL2 (CpG5)

 − 1.531702946*ELOVL2(CpG7)

 + 1.000713439*FHL2(CpG1)

 − 0.674486107*FHL2(CpG4)

 + 1.170946852*FHL2(CpG5)

 + 0.816922873*FHL2(CpG7)

 − 0.641544097*FHL2(CpG8)

 − 0.958506956*ITGA2B(CpG1)

 + 0.211886446*ITGA2B(CpG2)

 − 0.008128604*ELOVL2(CpG3)2

 + 0.016263489*ELOVL2(CpG7)2

 − 0.026586745*FHL2(CpG5)2

 + 0.008172081*ITGA2B(CpG1)2

 − 0.026087696*PDE4C (CpG3)2

 + 0.014023034*PDE4C(CpG5)2

  1. To determine DNAmAge, coefficients must be multiplied by the percentage of CpG methylation