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Table 2 Associations between DNAm age acceleration in tumor tissue and tumor characteristics in Hong Kong breast cancer women

From: DNA methylation age in paired tumor and adjacent normal breast tissue in Chinese women with breast cancer

Characteristic

β (SE)a

P valuea

Tumor subtype

  

 Luminal A

Ref.

−

 Luminal B

5.11 (3.1)

0.098

 HER2

− 7.92 (4.2)

0.064

 Basal

− 9.87 (5.2)

0.059

TP53- Mut vs. TP53- WT

− 9.89 (3.5)

0.006

Tumor mutation burden

− 0.58 (0.2)

0.017

PGSb

− 6.29 (4.8)

0.195

ESR1

0.81 (0.5)

0.084

  1. Bold denotes a statistical significant result with P-value < 0.05
  2. aResults were obtained from running multivariate linear regression analysis, where age acceleration was treated as the outcome
  3. bPercent genome with copy number alterations
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Clinical Epigenetics

ISSN: 1868-7083

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