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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Longitudinal DNA methylation profiling of the rectal mucosa identifies cell-specific signatures of disease status, severity and clinical outcomes in ulcerative colitis cell-specific DNA methylation signatures of UC

Fig. 1

DNAm and corresponding gene signatures associated with UC at diagnosis: a Comparison of estimated cell proportions for epithelial, immune cells and fibroblasts between rectal biopsies from UC patients (at diagnosis) and controls. p Values are shown from the Wilcoxon test. b Cell-specific epigenome-wide analysis (EWAS) comparing UC patients to controls. The blue line represents significant differential methylation at false discovery rate (FDR) < 0.05, and the red line represents Bonferroni-adjusted genome-wide significance (p < 1e−08). c The volcano plot shows differentially expressed genes that are associated with cell specific CpG sites in UC for all three cell types. x-axis shows log2FC and y- axis shows the negative log p-value detected for each gene in DE analysis. d The lollipop diagram shows the top 10 Gene Ontology (GO) biological processes identified as enriched in sets of differentially methylated CpG sites (blue) and differentially expressed genes in UC. Y- axis shows the number of CpGs and genes detected for each GO term

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Clinical Epigenetics

ISSN: 1868-7083

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