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Table 5 Top regional 5-hmC differences related to PFDA exposure

From: Mediation effects of DNA methylation and hydroxymethylation on birth outcomes after prenatal per- and polyfluoroalkyl substances (PFAS) exposure in the Michigan mother–infant Pairs cohort

Chromosome

Position start

Position end

p-value

BH q−value

Number probes

Gene name

1

47780564

47783925

8.74E−07

6.92E−04

4

TRABD2B

6

97600110

97602965

2.82E−06

9.56E−04

4

ENSG00000271860.9

1

9775829

9776507

2.50E−07

5.24E−04

3

CLSTN1

12

78682326

78683267

4.41E−07

5.24E−04

3

 

4

88736370

88738396

1.60E−06

7.20E−04

3

FAM13A

7

9787186

9789187

4.58E−06

0.0012

3

 

6

79762944

79765119

1.09E−05

0.002

3

 

1

7614319

7617563

1.53E−05

0.002

3

CAMTA1

6

19619236

19620188

1.54E−05

0.002

3

LNC-LBCS

4

12758255

12761141

1.58E−05

0.002

3

 

6

95632160

95632937

1.64E−05

0.002

3

 

5

84773408

84774104

1.78E−05

0.002

3

 

2

93797164

93798143

2.18E−05

0.0022

3

 

4

9649184

9650927

3.28E−05

0.0024

3

ENSG00000287117.1

7

99653239

99655923

3.68E−05

0.0024

3

CYP3A5

7

73708261

73711118

5.92E−05

0.0028

3

STX1A

8

72631834

72631937

1.19E−04

0.0033

3

KCNB2

1

82669840

82672849

4.25E−04

0.0049

3

ENSG00000233290.4

3

32696525

32699280

6.69E−04

0.0055

3

CNOT10

7

4697496

4698880

7.72E−04

0.0058

3

FOXK1

  1. Describes the chromosomal locations of significant regions of 5-hmC related to PFDA exposures. p represents the uncorrected p-value, and q represents the Benjamini–Hochberg (BH) corrected q-value