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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Mediation effects of DNA methylation and hydroxymethylation on birth outcomes after prenatal per- and polyfluoroalkyl substances (PFAS) exposure in the Michigan mother–infant Pairs cohort

Fig. 4

Overlap for significant 5-hydroxymethylcytosine (5-hmC, q < 0.05) sites (A) and genes (B) by PFAS (n = 70). Each plot and Venn diagram inset shows the overlap between all PFAS in the present study. C Lists the three genes that overlapped between at least five PFAS. β corresponds the beta regression coefficient estimate representing exp(estimate) differences for each log-fold unit change in PFAS concentration or categorical PFAS detection, p represents the uncorrected p-value, and q represents the Benjamini–Hochberg corrected q-value. Abbreviations: MeFOSAA: 2-(N-methyl-perfluorooctane sulfonamido) acetic acid; MYH9: myosin heavy chain 9; PARD3: Par-3 family cell polarity regulator; PFAS: per-/polyfluoroalkyl substances; PFHxS: perfluorohexanesulphonic acid; PFDA: perfluorodecanoic acid; PFNA: perfluorononanoic acid; PFOS: perfluorooctanesulfonic acid; PFUnDA: perfluoroundecanoic acid; SHANK2: SH3 and multiple ankyrin repeat domains 2

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Clinical Epigenetics

ISSN: 1868-7083

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