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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Mediation effects of DNA methylation and hydroxymethylation on birth outcomes after prenatal per- and polyfluoroalkyl substances (PFAS) exposure in the Michigan mother–infant Pairs cohort

Fig. 2

Significant total methylation sites (n = 141). Each row represents an individual PFAS. On the left, Manhattan plots describe the chromosomal location of all sites and corresponding Benjamini–Hochberg corrected p-value (q-value), with the sites significantly associated with PFAS labeled and noted with solid triangles. On the right, volcano plots depict all PFAS-site associations by effect estimate representing differences for each log-fold unit change in PFAS concentration or categorical PFAS detection and Benjamini–Hochberg corrected p-value (q-value), with the statistically significant sites noted in solid triangles. Dashed lines on both represent q-value = 0.05. Abbreviations: PFAS: per-/polyfluoroalkyl substances; PFHxS: perfluorohexanesulphonic acid; PFDA: perfluorodecanoic acid; PFNA: perfluorononanoic acid; PFOA: perfluorooctanoic acid; PFOS: perfluorooctanesulfonic acid

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Clinical Epigenetics

ISSN: 1868-7083

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