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Fig. 5 | Clinical Epigenetics

Fig. 5

From: H4-methylation regulators mediated epitranscriptome patterns and tumor microenvironment infiltration characterization in hepatocellular carcinoma

Fig. 5

Construction of H4M signature. A Consensus matrix heatmap defining three geneClusters (k = 3) and their correlation areas. B Kaplan-Meier survival analysis for H4M geneClusters. C The H4M modification patterns and other clinical characteristics were used as patient annotations. Differences in the expression levels of 133 hub genes were exhibited between the three distinct geneClusters. D-E The process of filtering genes by LASSO regression model. F Kaplan–Meier survival analyses for the high-H4Mscore and low-H4Mscore groups. G H4Mscore distribution, survival status of patients, and gene expression of 39 feature genes in H4M-related signature. H ROC curves measuring the predictive value of the H4Mscore signature. *, **, and *** mean p < 0.05, < 0.01, and < 0.001, respectively

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Clinical Epigenetics

ISSN: 1868-7083

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