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Fig. 1 | Clinical Epigenetics

Fig. 1

From: H4-methylation regulators mediated epitranscriptome patterns and tumor microenvironment infiltration characterization in hepatocellular carcinoma

Fig. 1

Expression and genomic variation landscape of 36 H4 methylation (H4M) regulators in hepatocellular carcinoma (HCC). A The main workflow of this study. B The mutation frequency of 36 H4M regulators in 371 patients with hepatocellular carcinoma from the TCGA-LIHC cohort. C Copy number variation (CNV) frequency of H4M regulators in TCGA-LIHC. D The interaction diagram of proteins involved in histone methylation, histone demethylation, regulation of response to DNA damage stimulus, regulation of epigenetic gene expression, regulation of DNA repair, regulation of mitotic cell cycle, and regulation of adaptive immune response. Red solid lines represent protein–protein interactions; pale blue dotted lines represent GO processes. The color bar from red to blue depicts the fold change of protein levels from increasing to decreasing. The significance of the pathways represented by − log (p value) was shown by color scales with dark purple as the most significant. E Principal component analysis of the 36 H4M regulators in normal and HCC patients (blue indicates normal and red indicates HCC patients). F Expression of 36 H4M regulators between normal and HCC patients. *, **, and *** mean p < 0.05, < 0.01, and < 0.001, respectively

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