Table 6 The top GREAT ontology enrichments for regions potentially related to diastolic blood pressure
Ontology database | Term name | Binom FDR Q-value | Binom region fold enrichment |
|---|---|---|---|
PANTHER pathway | Inflammation mediated by chemokine and cytokine signaling pathway | 1.42E-12 | 1.50 |
PANTHER pathway | Thyrotropin-releasing hormone receptor signaling pathway | 9.07E-12 | 1.82 |
PANTHER pathway | Nicotine pharmacodynamics pathway | 2.13E-11 | 2.27 |
PANTHER pathway | Endogenous cannabinoid signaling | 2.44E-11 | 2.35 |
PANTHER pathway | Cytoskeletal regulation by Rho GTPase | 2.68E-10 | 1.83 |
PANTHER pathway | Notch signaling pathway | 1.52E-09 | 1.93 |
PANTHER pathway | Histamine H1 receptor-mediated signaling pathway | 2.86E-09 | 1.82 |
PANTHER pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | 6.39E-09 | 1.64 |
PANTHER pathway | Angiogenesis | 4.17E-08 | 1.35 |
PANTHER pathway | 2-Arachidonoylglycerol biosynthesis | 1.35E-07 | 3.31 |
PANTHER pathway | Nicotinic acetylcholine receptor signaling pathway | 7.36E-07 | 1.52 |
PANTHER pathway | Corticotropin-releasing factor receptor signaling pathway | 1.51E-06 | 1.94 |
PANTHER pathway | p53 pathway by glucose deprivation | 2.02E-06 | 2.21 |
PANTHER pathway | Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction | 2.16E-06 | 1.83 |
PANTHER pathway | Angiotensin II-stimulated signaling through G proteins and beta-arrestin | 6.23E-06 | 1.79 |
PANTHER pathway | Wnt signaling pathway | 7.41E-05 | 1.17 |
PANTHER pathway | GABA-B receptor II signaling | 1.80E-04 | 1.54 |
PANTHER pathway | Blood coagulation | 1.64E-03 | 1.64 |
PANTHER pathway | Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade | 5.21E-03 | 1.40 |
PANTHER pathway | TGF-beta signaling pathway | 7.04E-03 | 1.22 |
PANTHER pathway | Beta3 adrenergic receptor signaling pathway | 2.62E-02 | 1.46 |
PANTHER pathway | PI3 kinase pathway | 3.04E-02 | 1.28 |
PANTHER pathway | FGF signaling pathway | 3.54E-02 | 1.16 |
PANTHER pathway | Hedgehog signaling pathway | 3.99E-02 | 1.40 |
PANTHER pathway | Toll receptor signaling pathway | 4.29E-02 | 1.30 |
MSigDB pathway | Ceramide signaling pathway | 1.96E-17 | 2.27 |
MSigDB pathway | RhoA signaling pathway | 1.56E-13 | 2.05 |
MSigDB pathway | p53 pathway | 3.68E-09 | 1.81 |
MSigDB pathway | VEGF signaling pathway | 5.46E-06 | 1.54 |
MSigDB pathway | Insulin signaling pathway | 3.20E-03 | 1.23 |