Epigenome-wide association study in Chinese monozygotic twins identifies DNA methylation loci associated with blood pressure

Wang, Weijing; Yao, Jie; Li, Weilong; Wu, Yili; Duan, Haiping; Xu, Chunsheng; Tian, Xiaocao; Li, Shuxia; Tan, Qihua; Zhang, Dongfeng

doi:10.1186/s13148-023-01457-1

Table 3 Results of causal inference analysis for systolic blood pressure and diastolic blood pressure

From: Epigenome-wide association study in Chinese monozygotic twins identifies DNA methylation loci associated with blood pressure

CpG No.	Chromosome	Position	HGNC symbol	Methylation to blood pressure					Blood pressure to methylation
CpG No.	Chromosome	Position	HGNC symbol	β_{self_change}	p_{self_change}	β_{co-twin_change}	p_{co-twin_change}	Absolute value of ratio	β_{self_change}	p_{self_change}	β_{co-twin_change}	p_{co-twin_change}	Absolute value of ratio
SBP
CpG1	chr3	84,330,462	SRRM1P2	0.640	0.247	− 2.869	0.046	4.483	− 0.001	0.307	0.001	0.198	–
CpG2	chr16	15,814,807	NDE1, MYH11	0.086	0.287	− 0.355	< 0.001	4.136	− 0.004	0.405	0.008	0.210	–
CpG3	chr13	87,444,790	TXNL1P1	0.628	0.212	− 2.764	0.001	4.403	− 0.001	0.208	0.002	0.035	1.746
CpG4	chr13	87,444,783	TXNL1P1	0.540	0.288	− 2.704	0.002	5.006	− 0.001	0.240	0.002	0.045	1.820
CpG5	chr2	130,937,909	SMPD4	0.080	0.041	0.290	< 0.001	3.650	0.004	0.456	− 0.017	0.006	4.545
CpG6	chr3	195,609,985	TNK2	0.209	0.041	0.322	0.006	1.538	− 0.003	0.602	− 0.012	0.062	–
CpG7	chr2	130,937,907	SMPD4	0.132	0.005	0.359	< 0.001	2.728	0.001	0.789	− 0.017	0.002	12.877
CpG8	chr1	64,880,619	CACHD1	− 0.091	0.019	− 0.300	0.015	3.309	− 0.005	0.533	0.022	0.080	–
CpG9	chr16	15,814,759	NDE1, MYH11	0.082	0.262	− 0.421	< 0.001	5.111	− 0.006	0.284	0.010	0.128	–
DBP
CpG1	chr1	228,195,277	WNT3A	− 0.745	0.102	− 2.312	< 0.001	3.102	− 0.001	0.538	− 0.003	0.353	–
CpG2	chr1	228,195,289	WNT3A	− 0.785	0.142	− 2.759	< 0.001	3.515	0.000	0.819	− 0.001	0.737	–
CpG3	chr1	228,195,292	WNT3A	− 0.787	0.157	− 2.875	< 0.001	3.655	0.000	0.936	0.000	0.907	–
CpG4	chr1	228,195,260	WNT3A	− 0.451	0.133	− 1.083	0.015	2.404	− 0.002	0.294	− 0.005	0.103	–
CpG5	chr7	25,898,451	LOC646588	− 0.111	0.864	− 1.332	0.040	11.959	0.001	0.623	0.003	0.217	–
CpG6	chr7	25,898,447	LOC646588	− 0.143	0.820	− 1.301	0.038	9.112	0.001	0.634	0.002	0.263	–
CpG7	chr6	66,373,850	EYS	0.143	0.700	− 0.402	0.317	–	0.012	0.094	0.038	< 0.001	3.234
CpG8	chr9	80,272,835	GNA14	− 0.078	0.761	0.121	0.670	–	0.011	0.062	− 0.021	0.010	1.877
CpG9	chr9	80,272,842	GNA14	− 0.098	0.724	0.156	0.608	–	0.011	0.070	− 0.021	0.007	2.013

DBP, diastolic blood pressure; SBP, systolic blood pressure

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ISSN: 1868-7083

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