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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Selenite as a dual apoptotic and ferroptotic agent synergizes with EGFR and KRAS inhibitors with epigenetic interference

Fig. 2

Selenite treatment altered DNA methylation machinery mainly at the protein level and altered the transcriptomic landscape. A The mRNA levels of DNA methylation machinery treated for 72 h were assessed by RT-qPCR and demonstrated upregulation in DNMT1 and TET1 in H1975 only. B Western blot analysis of H1975 and H358 cell lysate treated for 72 h demonstrated downregulation in DNMT1 and upregulation in TET1. C Heatmap of the differentially expressed genes

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Clinical Epigenetics

ISSN: 1868-7083

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