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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Selenite as a dual apoptotic and ferroptotic agent synergizes with EGFR and KRAS inhibitors with epigenetic interference

Fig. 1

Selenite-induced cell cycle arrest and cell death. A Cell viability and IC50 of H1975 and H358 treated with selenite at 24, 48, and 72 h were assessed by MTS assay. B Flow cytometry revealed cell cycle arrest induced by sodium selenite at 72 h. C Western blot analysis of cleaved PARP and cleaved caspase 3 in 72-h selenite-treated cells demonstrated apoptosis. D Western blot analysis showed upregulation of cytochrome C, BIM, and NOXA, representative markers of the intrinsic pathway of apoptosis caused by 72-h selenite treatment

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Clinical Epigenetics

ISSN: 1868-7083

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