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Fig. 4 | Clinical Epigenetics

Fig. 4

From: EBS-seq: enrichment-based method for accurate analysis of 5-hydroxymethylcytosine at single-base resolution

Fig. 4

Gene-body 5hmC is associated with gene expression in CRC. Heatmaps illustrating the relationship between gene expression and gene-body 5hmC content were created from (A) EBS-seq data and (B) hmC-SEAL data. Heatmap was created using RPKM-normalized read counts within gene bodies. Correlation coefficients were calculated using Pearson correlation. C Heatmap showing correlations between EBS-seq and hmC-SEAL. Heatmap was created using RPKM-normalized read counts within gene bodies. Correlation coefficients were calculated using Pearson correlation. D, E Box plots showing gene-body 5hmC content in each CRC sample according to gene expression by utilizing (D) EBS-seq data and (E) hmC-SEAL data

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Clinical Epigenetics

ISSN: 1868-7083

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