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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Chromatin remodeler Activity-Dependent Neuroprotective Protein (ADNP) contributes to syndromic autism

Fig. 4

Cancer-related associations of ADNP. (A) Table of types of ADNP mutations found in PanCancer. (B) 3D structure of ADNP retrieved from Alphafold database; light green domains represent zinc (ZN) fingers and the purple domain represent the homeobox domain; lime yellow spheres represent alpha carbon of residues in which genetic mutations cause frameshifts and incorporation of a premature stop codon. Leu 831 is reported as a reference position of hot locations that are often mutated into early stop codon/frameshift causing HVDAS. (C) Word cloud adapted from the OncoVar website, referring to top cancer drivers, which includes several known ADNP interactors

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