A variability in response of osteoclasts to zoledronic acid is mediated by smoking-associated modification in the DNA methylome

Tan, Qihua; Møller, Anaïs Marie Julie; Qiu, Chuan; Madsen, Jonna Skov; Shen, Hui; Bechmann, Troels; Delaisse, Jean-Marie; Kristensen, Bjarne Winther; Deng, Hong-Wen; Karasik, David; Søe, Kent

doi:10.1186/s13148-023-01449-1

Table 3 Significant GO terms enriched in genes linked to CpGs differentially methylated for smoking-dependent effect of IC50

From: A variability in response of osteoclasts to zoledronic acid is mediated by smoking-associated modification in the DNA methylome

ID	Description	BgRatio	p-value	p adjust	q-value	Count
GO:0106310	protein serine kinase activity	360/18368	2.99E-07	0.000361978	0.000335646	118
GO:0005109	frizzled binding	37/18368	2.90E-06	0.001755807	0.001628082	21
GO:0008569	minus-end-directed microtubule motor activity	18/18368	4.59E-05	0.018510734	0.017164191	12
GO:0022836	gated channel activity	340/18368	6.92E-05	0.02091644	0.019394897	103
GO:0015491	cation:cation antiporter activity	27/18368	0.000108589	0.024865369	0.023056566	15
GO:0017081	chloride channel regulator activity	17/18368	0.000144847	0.024865369	0.023056566	11
GO:0004674	protein serine/threonine kinase activity	386/18368	0.000150575	0.024865369	0.023056566	113
GO:0035591	signaling adaptor activity	81/18368	0.000164535	0.024865369	0.023056566	32
GO:0003779	actin binding	441/18368	0.000203603	0.027350723	0.025361125	126
GO:0003774	cytoskeletal motor activity	114/18368	0.000250792	0.030320759	0.028115109	41
GO:0030020	extracellular matrix structural constituent conferring tensile strength	41/18368	0.000324922	0.035711918	0.033114094	19
GO:0051959	dynein light intermediate chain binding	27/18368	0.000478613	0.039378783	0.036514217	14
GO:0015276	ligand-gated ion channel activity	143/18368	0.000503203	0.039378783	0.036514217	48
GO:0022834	ligand-gated channel activity	143/18368	0.000503203	0.039378783	0.036514217	48
GO:0046873	metal ion transmembrane transporter activity	430/18368	0.000516627	0.039378783	0.036514217	121
GO:0008146	sulfotransferase activity	52/18368	0.000553713	0.039378783	0.036514217	22
GO:0017046	peptide hormone binding	52/18368	0.000553713	0.039378783	0.036514217	22
GO:0003777	microtubule motor activity	69/18368	0.000617837	0.041498063	0.038479332	27

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ISSN: 1868-7083

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