Fig. 2

Bioinformatics analysis of PLCD1 gene in tissues. a Comparison of PLCD1 expression level between normal and tumor renal samples through GENT2 database. N: normal, T: tumor. b mRNA expression of PLCD1 based on sample types in KIRC (upper lane) and KIRP (bottom lane) patients. c PLCD1 proteomic expression profile in normal and primary tumor samples from KIRC patients. The data of b and c were retrieved from UALCAN database. d Oncoprint plots showing genetic alteration rates of PLCD1 in KIRC and renal non-clear cell carcinoma patients from cBioportal database. e DNA methylation-level comparison between case and control samples from KIRC (left one) and KIRP (right one) patients through EWAS Data Hub. f Scatter diagram depicting the negative correlation between PLCD1 methylation and mRNA expression. The raw data was extracted from EWAS Data Hub. g Kaplan–Meier curves illustrating the association of PLCD1 expression and methylation h with the overall survival of KIRC (left lane) and KIRP (right lane) patients, respectively. The plots of g were captured from TIMER 2.0 database and h from EWAS Data Hub. KIRC Kidney renal clear cell carcinoma; KIRP kidney renal papillary cell carcinoma