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Table 4 Significant associations between significant CpGs identified in blood lipid (exposure/outcome) EWAS among survivors of European ancestry and the expression of their nearby genes (FDR < 0.05)

From: Distinct DNA methylation signatures associated with blood lipids as exposures or outcomes among survivors of childhood cancer: a report from the St. Jude lifetime cohort

CpG

Gene Ensembl ID

Nearby gene

Effect

SE

P

FDR

cg01620154

ENSG00000061273

HDAC7

− 3.68

0.63

4.43E−08

1.24E−06

cg23475474

ENSG00000168646

AXIN2

− 4.30

0.72

2.54E−08

1.24E−06

cg01758046

ENSG00000117298

ECE1

2.28

0.56

8.54E−05

1.34E−03

cg07507418

ENSG00000124496

TRERF1

− 3.49

0.87

9.55E−05

1.34E−03

cg00543524

ENSG00000100354

TNRC6B

− 1.49

0.39

1.69E−04

1.89E−03

cg08641767

ENSG00000107745

MICU1

− 1.74

0.47

2.75E−04

2.57E−03

cg01507280

ENSG00000015676

NUDCD3

3.13

0.92

8.48E−04

6.78E−03

cg01710244

ENSG00000123213

NLN

5.50

1.69

1.45E−03

1.01E−02

cg18807499

ENSG00000121057

AKAP1

− 3.88

1.45

8.27E−03

4.63E−02

cg24040155

ENSG00000162337

LRP5

− 6.12

2.28

8.09E−03

4.63E−02

  1. SE standard error, FDR false discovery rate