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Table 2 Overlapping significant CpGs in exposure and outcome EWAS of blood lipid among survivors of European ancestry in SJLIFE cohort

From: Distinct DNA methylation signatures associated with blood lipids as exposures or outcomes among survivors of childhood cancer: a report from the St. Jude lifetime cohort

CpG

chr_hg38

Start_hg38

Nearby gene gengebnegene

EWAS

Lipid

Effect

SE

P

cg00574958

11

68840153

CPT1A

Exposure

TC

− 2.25E−03

3.30E−04

2.15E−11

     

TG

− 1.28E−03

1.20E−04

1.50E−24

cg05325763

11

68840250

CPT1A

 

TC

− 1.84E−03

3.20E−04

1.31E−08

     

TG

− 1.13E−03

1.17E−04

1.48E−20

cg17058475

11

68840268

CPT1A

 

TC

− 2.05E−03

3.52E−04

8.81E−09

     

TG

− 1.11E−03

1.31E−04

1.27E−16

ch.1.829344F

1

24657005

SRRM1

Outcome

HDL

6.39

0.89

1.03E−12

     

LDL

17

2.19

2.18E−14

     

TC

25.51

2.94

1.36E−17

cg20935223

7

6168606

CYTH3

 

HDL

8.30

1.50

3.96E−08

     

LDL

22.27

3.75

3.99E−09

     

TC

30.22

5.02

2.40E−09

cg21750129

9

71249778

TRPM3

 

HDL

7.03

1.05

3.97E−11

     

LDL

15.86

2.64

2.63E−09

     

TC

24.53

3.52

5.73E−12

  1. EWAS epigenome-wide association study, chr_hg38 chromosome in GRCh38/hg38, Start_hg38 CpG start position in GRCh38/hg38, SE standard error, HDL high-density lipoprotein, LDL low-density lipoprotein, TG triglycerides, TC total cholesterol