Regulatory networks driving expression of genes critical for glioblastoma are controlled by the transcription factor c-Jun and the pre-existing epigenetic modifications

Table 1 Top 15 TF binding probabilities in glioma enhancers calculated by the hypergeometric test

TF model	Occurrences in enhancers	Occurrences in the genome	Hypergeometric test (p value)	Hypergeometric test (adj. p value)
FOSL1_0_A	128	597	1,20723E−42	7,58142E−40
FOSL2_0_A	137	726	4,86818E−39	1,52861E−36
JUNB_0_A	115	544	7,50317E−38	1,57066E−35
JUND_0_A	123	623	3,12176E−37	4,90116E−35
FOS_0_A	119	626	1,9905E−34	2,50007E−32
BACH2_0_A	67	273	1,21946E−26	1,27636E−24
JUN_0_A	94	524	1,38731E−25	1,24462E−23
NFE2_0_A	71	344	2,45514E−23	1,92728E−21
BACH1_0_A	87	494	3,08603E−23	2,15336E−21
FOSB_0_A	96	585	3,7038E−23	2,32598E−21
NF2L2_0_A	63	279	4,66643E−23	2,66411E−21
MAFB_0_B	33	147	9,6426E−13	5,04629E−11
ZN554_1_D	48	302	7,42587E−12	3,58726E−10
MAFF_1_B	30	134	1,0909E−11	4,89348E−10
MAFK_0_A	16	41	8,72968E−11	3,65483E−09