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Table 3 Top 20 differentially expressed transcripts between female African American patients with SSc and controls ranked by absolute effect size

From: Distinct genome-wide DNA methylation and gene expression signatures in classical monocytes from African American patients with systemic sclerosis

Gene

Chr

Start (kb)

End (kb)

Strand

logFC

logCPM

p Value

Adjusted p value

COL9A2

1

40,766

40,883

−

− 1.18

3.04

1.26E−04

0.25

OBSCN

1

228,296

228,495

 + 

− 1.13

2.13

5.01E−04

0.25

PPP1R14B

11

64,012

64,114

−

− 0.65

2.53

2.17E−04

0.25

GDAP1

8

75,163

75,279

 + 

0.57

4.1

3.66E−04

0.25

TMC8

17

76,027

76,139

 + 

− 0.54

6.38

5.50E−05

0.25

ZNF654

3

88,088

88,194

 + 

0.43

4.19

2.37E−04

0.25

KYNU

2

143,535

143,735

 + 

0.43

7.52

3.25E−04

0.25

KLF6

10

3818

3927

−

0.42

9.52

1.94E−04

0.25

INSIG2

2

118,746

118,868

 + 

0.41

3.65

2.79E−04

0.25

SLC35B3

6

8,413

8,536

−

0.41

4.39

3.10E−04

0.25

POT1

7

124,470

124,670

−

0.41

4.64

4.27E−04

0.25

HIVEP3

1

42,284

42,484

−

− 0.4

5.13

2.65E−04

0.25

HPSE

4

84,216

84,356

−

0.4

6.6

6.95E−05

0.25

MDM2

12

69,102

69,239

 + 

0.37

7.08

1.42E−04

0.25

ABHD5

3

43,632

43,764

 + 

0.36

5.8

4.49E−04

0.25

RNF146

6

127,488

127,610

 + 

0.36

5.85

4.66E−04

0.25

IVD

15

40,598

40,714

 + 

− 0.34

5.67

2.20E−04

0.25

SMARCA4

19

10,972

11,172

 + 

− 0.31

7.93

2.97E−04

0.25

PLD1

3

171,428

171,628

−

0.27

5.99

1.78E−04

0.25

CYTH4

22

37,578

37,711

 + 

− 0.26

7.88

1.71E−04

0.25

  1. Genes are shown, along with location, strand, logarithm fold change (logFC), logarithm of counts per million reads (logCPM), unadjusted and adjusted p values