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Fig. 2 | Clinical Epigenetics

Fig. 2

From: DNA methylation as a potential mediator of the association between indoor air pollution and neurodevelopmental delay in a South African birth cohort

Fig. 2

Causal mediation analysis for the association between PM10 (exposure) and cognitive neurodevelopment (outcome) using CpG sites identified with high-dimensional mediation analysis methods. This figure presents estimates for indirect effect (IDE), direct effect (DE), total effect (TE), and proportion mediated (PM) for CpG sites with both significant IDE and TE. Significant total effects were found only for the cognitive neurodevelopmental domain (no significant total effects were identified for general adaptive behavior, language, or motor neurodevelopmental domains). IDE, DE, and TE effect estimates have been multiplied by the PM10 interquartile range (IQR) (58.78 µg/m3) observed in this cohort and thus these effect estimates represent the estimated effects on BSID-III cognitive score per one IQR increase in prenatal PM10 exposure

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Clinical Epigenetics

ISSN: 1868-7083

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