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Table 2 DNAm sites with significant interaction between maternal methylation and newborn sex on neonatal methylation in the BBC and IOWBC

From: Sex differences in the intergenerational link between maternal and neonatal whole blood DNA methylation: a genome-wide analysis in 2 birth cohorts

DNAm site

Chr

BP

Mother–newborn pairs from the BBC

IOWBC – early-pregnancy pairs

IOWBC – pre-pregnancy pairs

Mapped gene

Functional annotation

Relation to CpG Island

Mother–newborn association

The interaction term of newborn sex and maternal DNAm level

Mother–newborn association P

The interaction term of newborn sex and maternal DNAm level

Mother–newborn association P

The interaction term of newborn sex and maternal DNAm level

P

FDR

Beta

s.e

P

FDR

 

Beta

s.e

P

 

Beta

s.e

P

cg23532648

X

44,169,550

7.2 × 10–29

7.4 × 10–24

0.515

0.080

3.9 × 10–10

0.0003

0.001

0.704

0.655

0.30

0.002

0.459

0.282

0.11

EFHC2

Body

Island

cg26346636

X

41,301,703

6.1 × 10–7

1.8 × 10–5

− 0.479

0.085

3.3 × 10–8

0.0104

0.01

0.195

0.491

0.70

0.0002

− 0.068

0.200

0.74

  

Island

cg10591659

X

41,306,768

1.5 × 10–18

1.2 × 10–15

0.454

0.082

5.3 × 10–8

0.0104

5.6 × 10–6

− 1.210

0.431

0.02

0.001

− 0.647

0.291

0.03

NYX

5'UTR/1stExon

 

cg00478198

X

49,644,500

2.7 × 10–6

6.9 × 10–5

− 0.283

0.051

5.8 × 10–8

0.0104

0.02

− 0.283

0.333

0.41

0.99

0.009

0.221

0.97

LOC158572 USP27X

TSS1500 5'UTR/1stExon

Island

cg06055266

X

53,111,187

4.4 × 10–8

1.8 × 10–6

− 0.275

0.051

1.3 × 10–7

0.0135

0.32

0.258

0.321

0.44

0.004

0.278

0.140

0.05

TSPYL2

TSS1500

N_Shore

cg00257859

X

9,815,644

4.1 × 10–28

2.4 × 10–23

0.404

0.075

1.3 × 10–7

0.0135

        

SHROOM2

Body

 

cg00881203

X

149,930,926

1.4 × 10–14

2.9 × 10–12

− 0.354

0.066

1.3 × 10–7

0.0135

        

MTMR1

Body

S_Shore

cg01490258

X

40,030,456

1.8 × 10–6

4.7 × 10–5

− 0.395

0.075

2.9 × 10–7

0.0260

0.14

− 0.635

0.788

0.44

0.70

− 0.037

0.173

0.83

BCOR

5'UTR

N_Shore

cg01911745

7

31,091,055

1.6 × 10–7

5.6 × 10–6

− 0.396

0.076

3.6 × 10–7

0.0287

        

ADCYAP1R1

TSS1500

N_Shore

cg01483293

18

59,251,006

2.8 × 10–5

0.0005

− 0.474

0.092

4.0 × 10–7

0.0289

           

cg01963240

14

54,421,117

8.4 × 10–6

0.0002

− 0.514

0.101

6.3 × 10–7

0.0413

3.2 × 10–14

− 0.716

0.387

0.09

0.18

0.274

0.308

0.38

BMP4

5'UTR

Island

cg25871420

X

23,348,969

9.5 × 10–15

2.1 × 10–12

0.380

0.076

8.3 × 10–7

0.0469

1.1 × 10–5

0.890

0.592

0.16

0.12

0.337

0.268

0.22

  

N_Shore

cg02927373

19

51,347,703

5.9 × 10–5

0.001

0.476

0.095

8.4 × 10–7

0.0469

        

LOC105372441

Body

 

cg06376279

X

19,585,128

1.3 × 10–19

1.5 × 10–16

0.423

0.085

9.5 × 10–7

0.0488

        

SH3KBP1

Body

 

cg04149024

X

153,656,891

8.0 × 10–6

0.0002

− 0.301

0.060

1.0 × 10–6

0.0493

0.11

0.438

0.445

0.35

0.57

0.029

0.173

0.87

ATP6AP1

TSS200

Island

  1. Chr, chromosome; BP, position; FDR, false discovery rate; CpG, cytosine–phosphate–guanine dinucleotide; s.e., standard error
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Clinical Epigenetics

ISSN: 1868-7083

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