Fig. 8

Determination of HF gene subgroups based on m⁷G subtype-associated DEGs. A GO enrichment analysis of DEGs between two m⁷G subtypes. BP, biological process, CC, cellular components, MF, molecular functions. B KEGG enrichment analysis of DEGs between two m⁷G subtypes. C Alluvial diagram showing the changes of m⁷G subtypes and m⁷G gene subgroups of HF. D PCA plot showing a remarkable difference in transcriptomes between two HF gene subgroups. E Heatmap of DEGs between two m⁷G gene subgroups. F The two HF gene subgroups exhibit distinct expression profiles of the 14 m⁷G RNA methylation regulators. ns = not significant, *p < 0.05, ***p < 0.010 vs. gene subgroup A. G The infiltration scores of 16 immune cells between two m⁷G gene subgroups. ns = not significant, *p < 0.05, **p < 0.01 vs. gene subgroup A. H The infiltration scores of 13 immune-related functions between two m⁷G gene subgroups. ns = not significant, *p < 0.05, **p < 0.01, and ***p < 0.001 vs. gene subgroup A. DEGs Differentially expressed genes, GO Gene ontology, KEGG Kyoto Encyclopedia of Genes and Genomes, PCA Principal component analysis