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Table 6 Top ten CpGs associated with parity as selected by the elastic net model based on variable importance

From: Parity is associated with long-term differences in DNA methylation at genes related to neural plasticity in multiple sclerosis

CpG

Chr

Position (bp)

Gene

Feature

Importance

cg26506013

16

28887830

 

IGR

100

cg25485991

17

8066461

VAMP2

TSS200

99.92

cg23367339

17

36622717

ARHGAP23

Body

99.91

cg08186508

14

68067006

PIGH

5′UTR

99.84

cg17070338

13

111268441

CARKD

Body

99.82

cg07360021

6

151186904

MTHFD1L

1stExon

99.68

cg23841819

1

204970383

NFASC

Body

99.48

cg11918372

2

48132755

FBXO11

5′UTR

99.24

cg27573735

3

82857144

  

99.08

cg12835012

4

183795785

  

98.91

  1. Chr, Chromosome; bp, base pair; IGR, intergenic region; TSS200, transcript start site (up to 200 bp 5′ of 5′UTR), promoter region; and 5′UTR, 5′ untranslated region
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Clinical Epigenetics

ISSN: 1868-7083

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