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Table 5 Cell-specific differentially methylated positions (csDMPs)

From: Parity is associated with long-term differences in DNA methylation at genes related to neural plasticity in multiple sclerosis

CpG

Chr

Position (bp)

Gene

Feature

Nulligravida mean*

Parous mean*

Est

SE

p

CD4+ T cells

cg14172633

1

185703557

HMCN1

TSS200

− 3.10

− 2.84

− 3.64

0.62

1.7 × 10−8

cg15145296

3

125709740

  

− 4.24

− 3.98

− 3.23

0.56

3.6 × 10−8

cg06032337

6

29648468

  

− 2.82

− 2.71

− 3.17

0.56

5.1 × 10−8

cg06818823

6

46459236

  

− 6.55

− 5.90

− 5.88

1.04

5.8 × 10−8

CD8+ T cells

cg01858500

17

68202566

  

− 3.57

− 3.52

− 4.27

0.71

1.1 × 10−8

cg08944170

1

248100614

OR2L13

1stExon

− 3.38

− 3.60

− 2.78

0.48

2.3 × 10−8

cg25577322

7

17338213

AHR

TSS200

− 6.33

− 6.94

− 8.32

1.45

4.0 × 10−8

cg16402757

10

35311004

CUL2

Body

− 2.14

− 2.05

− 2.14

0.38

4.6 × 10−8

cg03495768

13

100637113

ZIC2

Body

− 2.98

− 3.07

− 3.05

0.54

6.1 × 10−8

cg04798314

1

246668601

SMYD3

Body

− 2.35

− 2.56

− 2.71

0.48

6.7 × 10−8

cg11738485

19

12877000

HOOK2

Body

− 2.79

− 2.51

− 2.42

0.43

6.8 × 10−8

cg20507276

1

248100600

OR2L13

1stExon

− 3.40

− 3.55

− 2.68

0.48

8.6 × 10−8

  1. CpG, cytosine-phosphate-guanine; Chr, chromosome; bp, base pair; Est, estimate (from linear regression); SE, standard error; and TSS200, transcript start site (up to 200 bp 5′ of 5′UTR) promoter region
  2. *Mean M-values reported as M-values used in cell-specific statistical analyses