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Table 2 Top 10 differentially methylated positions (DMPs) ranked by absolute effect size (∆meth)

From: Parity is associated with long-term differences in DNA methylation at genes related to neural plasticity in multiple sclerosis

CpG

Chr

Position (bp)

Gene

Feature

∆meth*

FDR

cg12036633

15

63758958

 

IGR

− 0.161

0.032

cg27484945

19

15561759

 

TSS1500

− 0.153

0.042

cg08779649

13

50194554

 

IGR

0.140

0.043

cg02122327

13

50194322

 

IGR

0.133

0.015

cg21415084

12

84218134

EPB41L5

IGR

0.114

0.039

cg03885684

2

120770471

 

TSS200

0.108

0.006

cg24000535

14

91110600

PRKCE

Body

− 0.083

0.017

cg08166072

2

46213920

 

Body

0.080

0.012

cg14248704

5

151470842

 

Body

0.074

0.006

cg10140164

9

75597328

IGR

 

− 0.072

0.017

  1. CpG, cytosine-phosphate-guanine; Chr, chromosome; bp, base pair; IGR, intergenic region; TSS200, transcript start site (up to 200 bp 5′ of 5′UTR) promoter region; and TSS1500, transcript start site (up to 1500 bp 5′ of 5′UTR) promoter region
  2. *Nulligravida to parous
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Clinical Epigenetics

ISSN: 1868-7083

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