Fig. 2

Chidamide inhibits cell proliferation and selectively induces the death of NKTL cells. A The effect of chidamide on the proliferation of 11 NKTL cell lines at 96 h posttreatment, represented as the concentration of chidamide required to inhibit proliferation by 50% (IC50). B–C Cell viability responses of NKTL cells to the HDAC inhibitors chidamide (1 μM), romidepsin (2.5 nM), belinostat (400 nM), SAHA (1 μM) and TSA (0.1 μM). D Dose-dependent effects of chidamide on cell proliferation over time in sensitive (KHYG1 and MEC04) and resistant (HANK1 and SNK6) cell lines. E Cell cycle assay of KHYG1, MEC04, HANK1 and SNT8 cells treated with chidamide for 72 h. F Annexin V/PI staining of KHYG1 and HANK1 cells treated with chidamide for 72 h. The results are expressed as the mean ± SD of three independent experiments