Table 1 Cohort characteristics. Statistical significance of differences between groups was assessed with ANOVA and Kruskal–Wallis test
No CAD group (control group) | Non-obstructive CAD | Obstructive CAD | p value | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
n | Mean, % | SD | Min | Max | n | Mean, % | SD | Min | Max | n | Mean, % | SD | Min | Max | ||
Chronological Age | 135 | 64.79 | 12.52 | 21.28 | 85.17 | 90 | 70.41 | 9.34 | 42.91 | 89.59 | 554 | 71.17 | 10.48 | 34.22 | 91.22 | < 0.001 |
DNAmA | 135 | 64.85 | 12.93 | 30.52 | 134.84 | 90 | 69.40 | 13.36 | 27.83 | 139.14 | 554 | 72.00 | 14.22 | 29.43 | 138.66 | < 0.001 |
DNAmAA | 135 | − 1.84 | 9.97 | − 42.26 | 58.34 | 90 | − 1.38 | 11.51 | − 37.05 | 58.46 | 554 | 0.67 | 12.04 | − 39.96 | 63.92 | 0.040 |
Systolic blood pressure (mmHg) | 105 | 134.12 | 19.80 | 84.00 | 191.50 | 72 | 131.42 | 17.64 | 92.00 | 181.50 | 444 | 135.63 | 21.34 | 92.50 | 205.50 | 0.255 |
HDL (mg/dl) | 125 | 56.69 | 18.32 | 22.00 | 102.00 | 82 | 55.27 | 17.91 | 26.00 | 114.00 | 537 | 48.83 | 15.36 | 14.00 | 108.00 | < 0.001 |
LDL (mg/dl) | 125 | 115.67 | 36.69 | 40.00 | 230.00 | 82 | 106.83 | 39.03 | 40.00 | 231.00 | 539 | 93.55 | 40.03 | 18.00 | 268.00 | < 0.001 |
Triglycerides (mg/dl) | 90 | 131.54 | 73.64 | 33.00 | 570.00 | 57 | 140.56 | 70.91 | 41.00 | 393.00 | 407 | 149.13 | 91.77 | 34.00 | 625.00 | 0.203 |
eGFR (ml/min/1.73m2) | 114 | 75.34 | 28.83 | 24.98 | 163.81 | 82 | 81.94 | 28.00 | 4.81 | 165.30 | 495 | 80.30 | 29.86 | 9.31 | 221.51 | 0.205 |
Lipoprotein (a) (nmol/l) | 133 | 40.64 | 53.23 | 5.00 | 240.20 | 88 | 45.29 | 62.57 | 5.00 | 256.30 | 542 | 62.00 | 82.22 | 5.00 | 478.20 | 0.005 |
BMI (kg/m2) | 120 | 28.00 | 5.32 | 17.40 | 48.40 | 84 | 27.70 | 5.50 | 18.10 | 51.10 | 508 | 27.68 | 4.65 | 17.10 | 46.30 | 0.812 |
Physical activity (RAPA) | 112 | 4.38 | 1.99 | 1 | 7 | 73 | 4.11 | 2.10 | 1 | 7 | 463 | 4.02 | 1.94 | 1 | 7 | 0.209 |
Alcohol consumption | ||||||||||||||||
Yes | 65 | 44.90 | 46 | 51.10 | 274 | 55.20 | 0.927 | |||||||||
No | 53 | 55.10 | 34 | 37.80 | 222 | 44.80 | ||||||||||
Currently smoking | ||||||||||||||||
Yes | 24 | 20.10 | 14 | 16.90 | 95 | 18.20 | 0.826 | |||||||||
No | 94 | 79.90 | 69 | 83.10 | 409 | 21.80 | ||||||||||
Diagnosed Type 2 Diabetes Mellitus | ||||||||||||||||
Yes | 26 | 19.30 | 20 | 22.20 | 166 | 30.00 | 0.023 | |||||||||
No | 109 | 80.7 | 70 | 77.80 | 388 | 70.00 | ||||||||||
Sex | ||||||||||||||||
Female | 83 | 61.5 | 37 | 41.1 | 118 | 21.3 | ||||||||||
Male | 52 | 38.5 | 53 | 58.9 | 436 | 78.7 | ||||||||||