Fig. 3

Pie charts representing percentage-distribution of overlapping regions (> 50 bp) between differentially methylated regions (DMRs) and histone enrichment (signal p > 50) mapped across the intragenic region of ITGB7. A ITGB7 DMRs (N = 2) in patients with t(4;14) translocation overlapped with histone marks in H929 cell line. B ITGB7 DMRs (N = 7) in patients with t(14;16) translocation overlapped with histone marks in MM.1S cell line. Chromatin-immunoprecipitation sequencing (ChIP-seq) data representing distribution and binding intensity of chromatin and transcription factors (TFs) at a region ± 10 kb upstream of the transcriptional start site (TSS) or up to the the 3’ end of ITGB7 in (C) primary B cells, compared to (D) H929 cells (representing t(4;14) translocation) and to (F) MM.1S cells (representing t(14;16) translocation). Differential upregulation (p < 0.05) of ITGB7 in both (E) t(14;14) subgroup and (G) t(14;16) subgroup, represented as a box chart with interquartile range between 25 and 75%, compared to control