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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Expression of integrin β-7 is epigenetically enhanced in multiple myeloma subgroups with high-risk cytogenetics

Fig. 2

A Heatmaps representing correlation (Pearson’s coefficient, R2) between differential expression (z-score) and median DNA methylation (z-score) of genes encoding 4 integrins (ITGA4, ITGA8, ITGB7, and ITGAE), 3 non-integrins (CDH2, DSG2, and VCAM1) and 2 co-stimulatory signal transduction-associated molecules (CD28, and CD86) in patient samples (N = 53) of multiple myeloma (MM) of IgH translocation and hyperdiploidy subgroups versus control. B Distribution of DNA methylation along the differentially methylated regions (DMRs) in promoter or body of the differentially methylated and expressed genes in MM molecular subgroups. C A correlation analysis (R2 with 95% confidence band) between median DNA methylation and expression of the key adhesion-related genes in MM cell lines representing 4 major IgH translocations

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