Liver saturated fat content associates with hepatic DNA methylation in obese individuals

Clinical Epigenetics

Table 3 Pearson correlations (r) between DNA methylation and mRNA expression at p value < 0.05

	CpG ID¹	Transcript ID²	r	p value
Gene expression (self)	cg14648237	PRKCA	0.585	0.0066*
Gene expression (self)	cg13160331	TSPO	− 0.537	0.0145
Gene expression (neighboring)	cg11821200	PRKAA1	0.274	0.0005*
	cg00437258	RAC1	− 0.565	0.0093
	cg07011711	SDHAF2	− 0.547	0.0124
	cg15892963	C14orf132	0.527	0.0168
	cg24191821	FCHSD2	0.504	0.0232
	cg19678564	KDM5B	0.468	0.0401
	cg26151675	GALE	0.461	0.0407
	cg14109579	DUSP28	− 0.459	0.0416
	cg00437258	ZDHHC4	0.449	0.0465
	cg18274619	ABTB1	-0.445	0.0490

¹Infinium HumanMethylation450 BeadChip-based DNA methylation and ²HumanHT-12 Expression BeadChip-based mRNA expression. PRKCA—Protein kinase C alpha; PRKAA1—protein kinase AMP-activated catalytic subunit alpha 1; TSPO—translocator protein; SDHAF2—succinate dehydrogenase complex assembly factor 2; RAC1—Rac family small GTPase 1; DUSP28—dual specificity phosphatase 28; ABTB1—ankyrin repeat and BTB domain-containing 1; C14orf132—chromosome 14 open reading frame 132; FCHSD2—FCH and double SH3 domains 2; GALE—UDP-galactose-4-epimerase; ZDHHC4—zinc finger DHHC-type containing 4; and KDM5B—lysine demethylase 5B. The Pearson correlation test was used for the analysis, and p value < 0.05 was considered statistically significant. *p value < 0.1 (adjusted for multiple testing)

ISSN: 1868-7083